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Moreover, at low doses, HNE exerts an anti-cancer effect, by inhibiting cell proliferation, angiogenesis, cell adhesion and by inducing differentiation and/or apoptosis in various tumor cell lines

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This work has been extended to the determination of a number of enzyme complex crystal structures which show that very large ligands are readily accommodated into this substrate binding site and in all, but one case, causes no significant movement of protein side-chains

In lupus-prone mice, 4-OI ameliorates renal immune complex deposition, decreases autoantibody production, and attenuates hyperactivation of immune cells via inhibition of JAK1 [64]