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Figure 3 Experimental studies conducted in cells and mouse models of cancer indicate that different Se compounds exert anticancer effects in cancer

The timing of selenium administration also warrants further investigation, particularly in the early phase of critical illness or trauma, when oxidative stress peaks

These findings establish the ROS/GSK3/GPX4 axis as a key driver of CO-induced ferroptosis, but how this pathway intersects with other cell-death pathways remains to be clarified