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This anti-inflammatory effect helps not just where the shot is given

If your body does not have all the right factors to effectively use fat for energy, it may decide to use muscle or other tissue the last thing you want when trying to lose weight is extensive muscle loss which can lower your metabolism

Whether the heptapeptide fragment fully recapitulates the parent proteins effects in vivo remains an unresolved question

By month fifteen, the trial's primary endpoint, the average participant had lost 15.2 percent of their starting weight, and the curve had become essentially horizontal [Garvey et al., Nature Medicine, 2022]