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In the three-chamber test, MIA mice demonstrated a profound impairment in social interaction, as evidenced by a significantly lower sociability index score of 6.7 1.3, compared to 29.5 1.3 in control mice

284 TNIK is a key regulator of the -catenin and TCF4 transcription complex, its pharmacological inhibition seems to be a promising therapeutic approach

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New blood vessels formation (angiogenesis) is controlled through the balance between pro- and anti-angiogenic factors so that the breakage of this balance leads to tumor growth 1