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353 These findings confirm that in the synovium, GLP-1R is expressed on two different cell types, macrophages and fibroblast-like synoviocytes, which are specialized cells distributed within the synovial intima and subintima, and these cell types play important roles in hyaluronic acid synthesis, metabolite processing, and clearance of matrix degradation fragments

Khavinson's group reported improved immune parameters and reduced respiratory infection rates in elderly cohorts receiving thymalin over 6-8 year observation periods Longevity data: A 15-year observational study of elderly patients receiving thymalin and epithalamin reported reduced mortality compared to untreated controls, with significant reductions in cardiovascular, cancer, and infectious disease mortality COVID-19 observations: During the pandemic, Khavinson's group published observations suggesting improved outcomes in elderly COVID-19 patients receiving thymalin, though these were not randomized controlled trials Evidence Assessment# Thymalin has the longest clinical history of any bioregulator, with decades of use in Russian medicine

Vaaga CE, Borisovska M, Westbrook GL

These actions lower blood sugar levels and suppress appetite, aiding in weight loss