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The BH 4 molecule serves as an essential cofactor for a number of enzymes involved in central metabolic processes, including tryptophan hydroxylases, nitric oxide synthase (NOS), alkylglycerol monooxygenase, and isoenzymes

These FMN particles appeared to lower riboflavin kinase expression in the microglia, preventing TNFR1/NF-B signaling and pro-inflammatory cytokine release 71

Though considered rare, some people have reported anaphylactic responses