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Here, we used human studies and in vitro models to demonstrate that NAPQI-derived thiomethyl metabolites identified using high-resolution mass spectrometry could serve to monitor NAPQI detoxification and elimination in patients (after intake at recommended dose or after intoxication), and to study inter-individual variability in NAPQI production

Confocal microscopy Confocal imaging was performed with a dual-camera Nikon W1 spinning disc microscope equipped with an sCMOS camera (Photometrix)

Proc Natl Acad Sci USA (2019) 116:133209