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Sleep architecture and dementia risk in adults: an analysis of 5 cohorts from the Sleep and Dementia Consortium

Below be detailed description of the present invention: Ubiquinone 10 Water-soluble hardly, therefore, in the preparation process, need to add solubilizing agent to ubiquinone 10 Carry out solubilising, mostly solubilizing agent commonly used is nonionic surfactant, and it is directly related with the concentration of salt in the solution that non-ionic surface active forms micellar stability, and the salt amount increases, and solubilizing effect and stability of solution all descend.Levocarnitine in this compositions can reduce solubilizing agent to ubiquinone as a kind of salt 10 Solubilization, make ubiquinone 10 The solubilising difficulty that becomes more, make it in storage process, be easier to separate out, and prior art all can not be realized.The specific non-ionic surface active agent of acceptable for pharmaceutical that the present invention selects is as solubilizing agent, in amount ranges of the present invention, to ubiquinone 10 Solubilizing effect good, can make stable compositions, can realize industrialization, toxic and side effects is little, can be used safely in the human injection

Richardson, J