All patients received a standard lifestyle intervention which included instruction on a reduced-calorie diet (approximately 500 kcal/day deficit) and increased physical activity counseling (recommended minimum of 150 min/week) that began with the first dose of ZEPBOUND, during the lead-in period, and continued throughout the trial
Key Points Despite recognition as an epidemic, obesity remains largely an unsolved medical problem, caused by the increased consumption of energy-dense, nutrient-poor foods and reduced physical activity
Clinical studies specifically evaluated markers of carbohydrate metabolism including fasting glucose, insulin levels, hemoglobin A1c (HbA1c), and insulin sensitivity indices
The largest studies, which include millions of individual dogs, 10,11 have observed the following estimates: 2 Nutritional Needs of Dogs Understanding Essential Nutrients for Dogs Modern domesticated dogs are generally omnivorous, readily consuming animal products (including live prey), fruits, vegetables, and other plant materials depending on food availability
