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In cases of severe, longstanding hypothyroidism, initial doses may also start at 12.5-25 mcg orally once a day

Low Dose Naltrexone is a pharmacologically active opioid antagonist, conventionally used at higher doses for opioid addiction and alcohol dependence

Outcomes Co-primary endpoints were percentage change in body weight from baseline to week 104 and achievement of weight loss of at least 5% of baseline weight at week 104