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doi: 10.1016/j.tifs.2022.04.010

Necroptosis, a form of regulated necrosis is typically mediated by activation of death receptors such as TNF receptor 1 (TNFR1), which ultimately lead to the assembly of a necrotic death complex (necrosome) [120], which consists of the receptor-interacting kinase 1 (RIP1), the receptor-interacting kinase 3 (RIP3), which interact through their homotypic interaction motif (RHIM) domains, as well as the pseudokinase mixed-lineage kinase domain-like protein (MLKL) [121]

High levels of superoxide may react with NO and generate peroxynitrite, which is a harmful free radical [136]