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The B12-conjugated GLP-1 agonist maintained comparable blood sugar control but with significantly better tolerance, less nausea, and fewer emetic episodes in both rat and mammalian models

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9 Thomas, M.K., et al., Dual GIP and GLP-1 Receptor Agonist Tirzepatide Improves Beta-cell Function and Insulin Sensitivity in Type 2 Diabetes

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YakymenkoOSchoultzIGullbergEStromMAlmerSWallonCet al

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