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Bmc Syst Biol

These environmental constraints may counteract SERF2-induced destabilization, thus preserving rG4 architecture despite protein binding

However, despite the absence of ferritinophagy we found that intracellular ferrous iron levels in IB3-1 cells (but not C38 cells) increased following erastin and FAC exposure, which requires further investigation as the pathways responsible for this increase in redox active iron in response to ferroptotic induction are currently unknown, but will become targets for future treatment interventions

In this review, we will present available evidence on the similarities and differences existing between isatuximab and daratumumab, ranging from their mechanisms of action to translational results, and an overview of recent, key clinical study findings for each agent, to better define their role in the management of patients with RRMM