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While the side effect toxicity is consistent with non-ferroptotic mechanisms involving oxidative stress, inflammation, mitochondrial impairment and other aberrant signalling leading to apoptosis and necroptosis, recent studies show that ferroptosis, a non-apoptotic, iron-dependent cell death pathway, is also involved in the pathophysiology of CT organ toxicity

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Luo Y, Zhou Y, Jiang H, Zhu Q, Lv Q, Zhang X, Gu R, Yan B, Wei L, Zhu Y, Jiang Z (2024) Identification of potential diagnostic genes for atherosclerosis in women with polycystic ovary syndrome

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