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These GPCRs include G protein-coupled receptor 41 (GPR41) (also known as FFAR3 (Free Fatty Acid Receptor 3)) (specifically responsive to butyrate), GPR43 (also known as FFAR2) (responsive to propionate, butyrate, and acetate), and GPR109A (responsive to butyrate alone)

This action of CHAC1, known as the blocker of NOTCH, effectively reduces the cell surface expression of the full-length NOTCH1 receptor, thus inhibiting the NOTCH1 signaling pathway and contributing to the suppression of T-ALL cell viability ( 6.9 Melanoma Melanoma is a type of skin cancer that arises from the melanocytes, the cells responsible for producing melanin, the pigment that gives skin its color