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Due to spin constraints, molecular O 2 cannot accept four electrons simultaneously to produce a water molecule

Reference: Japjec M, Horvat Pavlov K, Petrovic A, et al

Neuroendocrine investigations: Research into hormone signaling interactions

While good responders ( n = 4) achieved complete remission (CR) or a complete remission with incomplete hematologic recovery (CRI), poor responders ( n = 10) only reached cytoreduction or stable disease after Venetoclax treatment (Supplementary Table 1)