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Secondary objectives were to (1) assess patients perceptions and attitudes related to their relationship with their HCP, (2) understand the patient journey through the healthcare system, and (3) assess barriers to self-management and diagnosis, patient perceptions of biological treatments, treatment expectations, and satisfaction with care

6 Future directions Recent evidence supports a paradigm shift in pain neuroscience, highlighting the cerebellum not merely as a motor structure but as a central hub that integrates sensory, affective, and cognitive dimensions of pain processing

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For some patients it may be advisable to titrate up to this target dose over several days