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After absorption, vitamin B12 binds in serum to specific B12-binding beta (transcobalamin) and B12-binding alpha1 globulin

Could theoretical concerns about receptor downregulation, disrupting natural growth factor signaling, or other homeostasis disturbances exist

Long-term health issues related to heavy alcohol use: Chronic high BAC levels can lead to serious health problems, including liver disease, brain damage, and heart problems