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Immunoblot analysis showed no changes in pro-caspase-3 level and no detectable cleaved caspase-3 after 15 hours of combined treatment (Figure 4D), suggesting that apoptosis was not involved

Reverse T3 is a competitive inhibitor of T3, blocking T3 from binding to its receptor and blocking T3 effect,reduces metabolism, suppresses D1 and T4 to T3 conversion, and blocks T4 and T3 uptake into the cell, all reducing intracellular T3 levels and thyroid activity

Journal: bioRxiv Year: 2023

Additionally, NF-B has a critical role in the metabolic reprogramming of cancer cells, promoting adaptive response to metabolic stress and thus contribute to tumor progression (Table 1)