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Clin Cancer Res 12(15):47554765

Oropesa AL, Garcia-Cambero JP, Soler F

A is formed by the sequential cleavage of the transmembrane amyloid precursor protein (APP) via - and -secretase to generate monomeric A, which then polymerizes to form soluble oligomers, protofibrils and insoluble amyloid fibrils, which are the main components of amyloid plaques in AD [153, 154]