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Dose adjustment: If high-dose supplements cause symptoms, consider splitting the dose throughout the day or discussing a lower-strength preparation with your healthcare provider

Even though the liver can store it, vitamin B12 must still be regularly consumed

A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1

Consistent with the prodifferentiation effects of ENL inhibitors and degraders on leukemia cells 54,57,58 , we also noted an increase in transcription of the myeloid differentiation marker ITGAM (encoding CD11b), which was confirmed by measuring cell surface expression of CD11b in the spleen and peripheral blood (Fig