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In summary, curcumin orchestrates a multi-dimensional anti-photoaging network through Keap1-Nrf2 pathway regulation, integrating antioxidant defense (low doses), cell cycle intervention (moderate doses), and pro-apoptotic effects (high doses)

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TLS most often occurs after the start of cytotoxic therapy in patients with high-grade lymphomas (particularly the Burkitt lymphoma subtype) and acute leukemias, or after treatment of large or fast-growing tumors

Evaluation of FASN inhibitors by a versatile toolkit reveals differences in pharmacology between human and rodent FASN preparations and in antiproliferative efficacy in vitro vs