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To further enhance the BBB properties of the models, the medium was supplemented with cARLA (250 M 8-(4-chlorophenylthio)adenosine 3,5-cyclic monophosphate sodium salt, 17.5 M Ro-20-1724, 3 mM LiCl, 3 M A83-01

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It is therefore likely that in addition to the glucose regulatory effects of oral magnesium in diabetes mellitus, it may also potentiate the antioxidant defense mechanism through its effects on glutathione production and action