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Sleep hygiene practices including consistent bedtimes, cool room temperatures, and limited screen exposure before bed support restorative sleep patterns

Probenecid is the main such agent used in the US

Trends in Molecular Medicine , 11(9), 421429

Once opened (punctured with a needle), refrigerate at 28C and use within 28 days the benzyl alcohol preservative prevents bacterial growth for 28 days after puncture, but efficacy declines after that