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[5] Beyond its antioxidant properties, ALA may serve as an essential cofactor for mitochondrial enzymatic complexes (notably the -ketoacid dehydrogenases) involved in oxidative metabolism

doi: 10.1002/adbi.202300095 90 EngelenMPScholsAMDoesJDGoskerHRDeutzNEWoutersEF

Despite remaining challenges in purification efficiency and batch standardization, these features collectively establish PDEVs as a promising, scalable, and low-immunogenic nanotherapeutic platform, rather than just an experimental delivery system