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Consequently, these factors participate in regulate ferroptosis and immune escape of ovarian cancer cells, highlighting new therapeutic targets that could alleviate chemotherapy resistance among ovarian cancer patients ( Germ cells require extremely high mitochondrial dynamics to maintain physiological characteristics, and a high-load operation of the mitochondrial respiratory chain is closely related to ROS production

By reducing catechol estrogen semiquinones to catechol estrogens (Figure 2) 52 and/or reacting with E 1 (E 2 )-3,4-Q, NAC prevents malignant transformation of human MCF-10F cells53 and mouse E6 mammary cells 39 treated with 4-OHE 2

Pagan FL, Hebron ML, Wilmarth B, Torres-Yaghi Y, Lawler A, Mundel EE, et al