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Similar to this, miR-638 has a role in spermatogenesis in pigs by controlling the growth and death of immature Sertoli cells by specifically altering the expression of the sperm-associated antigen 1 (SPAG1) gene [212]

o Advise male patients with female partners of reproductive potential to use effective contraception during treatment with IBRANCE and for at least 3 months after the last dose [see Use in Specific Populations (8.3)]