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This condition occurs when the GI tracts protective barrier becomes loose, allowing particles to escape into the bloodstream

Why It Matters High levels of urinary DPD indicate accelerated bone breakdown , which can occur in: Osteoporosis and osteopenia Postmenopausal bone loss Hyperparathyroidism Certain cancers with bone metastases Chronic corticosteroid use Monitoring DPD levels provides early warning of skeletal imbalance, often before bone density scans reveal significant changes

Therefore, it is necessary to search for new therapeutic possibilities

Presently, the drugs available for treatment, including crizotinib or erlotinib, are tyrosine kinase inhibitors (TKIs) for cancer treatment (primarily lung adenocarcinoma), exhibiting EGFR mutations or EML4-ALK fusions