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Description

Recombinant antigen vaccine made up of Ag2/PRA (antigen 2/PRA) and CSA (Coccidioides-specific antigen) has shown favorable survival in mice suffering from coccidioidomycosis (313), caused by the endemic fungi Coccidioides immitis in immune-competent individuals in the southwestern United States and northwestern Mexico

Established treatments (e.g., metformin, thiazolidinediones, lifestyle interventions) already modulate metabolic and inflammatory axes and may have indirect effects on neutrophil priming and NETosis