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It could potentially be important in cognitive function and neurodegenerative diseases.[ref] Animal studies show that thiamine could improve cognition via modulating GSK-3B expression.[ref] In hospitalized patients with sepsis, a combination of IV thiamine, vitamin C, and hydrocortisone vastly improved the mortality rate compared to a control group.[ref] An animal study of induced myocardial infarction (heart attack) showed that benfotiamine administered before and after the heart attack had improved cardiac markers.[ref] Thiamine deficiency (mild or severe) is significantly associated with cognitive impairment and mood changes in cancer patients.[ref] A 2026 genome-wide association study paired with Mendelian randomization found that thiamine transport and activation are key in intestinal motility and IBS-C

This is often because circulating levels are subject to varying levels of homeostatic regulation, reflecting not only intake but also absorption, distribution across tissues, metabolism to other compounds, and excretion, he says. Johanna Lampe, PhD, RD, research professor in the Department of Epidemiology at the University of Washington School of Public Health and associate director of the Public Health Services Division at Fred Hutchinson Cancer Research Center in Seattle, says about 95% of TMA is converted to TMAO in the liver