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Ignoring this could lead to a peptide losing activity faster (for instance, through degradation of sensitive bonds)

Int J Cell Biol 2013, 638083

In the case of methionine, the average total pool size in Taipei was measured to be 2 g/kg dry weight (DW), which is equivalent to approximately 13,000 pmol/mg DW, while the average measured free methionine concentration was only approximately 1.4 pmol/mg DW

The immune system produces autoantibodies against nuclear components (DNA, histones, ribosomes), and immune complex deposition causes inflammation in kidneys, skin, joints, brain, and blood vessels