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There's not enough evidence to show what the effects may be of taking excessive doses of vitamin B12 supplements each day

This is because acute surges in blood glucose and insulin that follow meals (postprandial period) are important contributors to the overall adverse effects caused by excessive glucose and insulin levels

As a result, most reports lack sufficient procedural detail to allow reproducible clinical implementation, and meaningful comparison across studiesparticularly those using different biologic agents such as platelet-rich plasma (PRP), extracellular vesicles (EVs), or scaffold-based platformsremains difficult

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