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Chronic stress-induced astrocytic dysfunction impairs glutamate clearance, leading to excessive activation of subthalamic nucleus (STN) neurons, which disrupts basal ganglia circuitry and exacerbates motor and sleep disturbances in PD [81,82,83]

After adjustments via Benjamini and Hochbergs approach for controlling the false discovery rate, the genes meeting the criteria of a P value =1.5 were considered to be differentially expressed genes