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Here, many potential contributories have been identified, including cerebral hypoperfusion, gastrointestinal dysbiosis, autonomic dysregulation, metabolic, muscular, and mitochondrial dysfunction, inflammatory stimulation, oxidative and/or nitrosative stress, immune abnormalities, autoimmunity, and endothelial dysfunction

Upon stimulation, procaspase 1, NLRP3, and apoptosis-associated speck-like protein (ASC) converge to form the NLRP3 inflammasome (Zheng et al

Pyruvate dehydrogenase kinase isoform 2 activity stimulated by speeding up the rate of dissociation of ADP

Vaccination against hepatitis A and B is recommended for individuals with chronic liver disease, in line with UK Health Security Agency (UKHSA) guidance