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10.1111/j.1749-6632.1998.tb09019.x Ann

Several mechanisms contributing to cisplatin-induced neurotoxicity have been suggested (Figure 2), including the loss of peripheral sensory neurons, changes in cell signaling cascades, changes to calcium homeostasis and signaling, oxidative stress, mitochondrial dysfunction and induction of apoptosis as a result of DNA platination (Meijer et al., 1999)