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Mechanistically, ligand engagement causes TLR9 to recruit the adaptor protein myeloid differentiation primary response 88, via its Toll/IL-1 receptor domain [127]

The newly formed Vitamin D diffuses passively from keratinocytes into dermal capillaries, where it rapidly binds to the high-affinity Vitamin D-binding protein (VDBP) in plasma, forming a VDBPVitamin D complex that enters systemic circulation [82, 83]

All experiments were repeated three times