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Konturek PC, Brzozowski T, Konturek SJ (2011) Gut clock: implication of circadian rhythms in the gastrointestinal tract

To investigate the severe liver damage and increased mortality observed in hepsin / mice during the early stages after APAP administration, we employed ultra-performance liquid chromatography-tandem mass spectrometry to measure levels of APAP-cysteine adducts in mouse liver tissue, which indirectly assesses the generation of the toxic APAP metabolite, NAPQI (Hairin et al

rather, it relies on the adequate provision of biochemical precursors and cofactors required to sustain and optimize this intrinsic detoxification system

DC = DC follow-up DC baseline