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June 18 Product: AbbVies Skyrizi Indication: Ulcerative colitis AbbVies blockbuster therapy Skyrizi now has further reach after the FDA greenlit the IL-23 antagonist for the treatment of moderately to severely active ulcerative colitis

The 12-month trial design enables us to assess senolytic-associated changes before and after treatment during the 3-month active treatment phase, track the reappearance of senescent cells after their removal during the 9-month post-treatment period, and evaluate disease trajectory differences over a one-year period (Figure 3)

Combination therapies: Orforglipron could be combined with other oral agents (e.g., oral GIP agonists, SGLT-2 inhibitors, phentermine) for enhanced efficacy, or formulated as a fixed-dose combination tablet

Because true deficiency needs diagnosis, our registered nurses suggest confirming low levels with bloodwork when possible