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In a comparative study, a more potent neuroprotective effect of 100 mg/kg b.w MP seed ethanolic extract for 14 days than estrogen was found if administered pre and post-induction of neurotoxicity via MPTP in a mouse model of PD

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For example, copper ions can lead to GSH depletion through two mechanisms: the direct downregulation via the redox reaction between Cu 2+ and intracellular GSH, and the activation of a Fenton-like reaction by generating Cu + to amplify oxidative stress ( in situ GSH in tumor triggered mCMSNs biodegradation and reduced Cu 2+ into Cu + for enhanced hydroxyl radical production, leading to a powerful inhibition effect on tumors (Liu et al., 2019)

In addition to transcriptional regulation, the expression of GPX4 is also regulated at the protein level [43]