Within the intricate gut-kidney axis pathological framework, these therapeutic mechanisms collectively demonstrate rhubarbs multifaceted intervention across four critical junctures: orchestrating intestinal microbiome remodeling through selective bacterial modulation, reinforcing intestinal barrier integrity via colonic epithelial strengthening, optimizing microbial metabolite profiles through uremic toxin reduction and correction of aberrant fermentation processes, and ultimately providing direct renal cellular protection by attenuating both glomerulosclerotic progression and interstitial fibrogenesis
91 Micheli L, Di Cesare Mannelli L, Mattoli L, Tamimi S, Flamini E, Garetto S, et al
5.1 The Role of Glutamine Metabolism in T Cells and NK Cells T cells and NK cells are the cytotoxic effector cells of productive immune response to cancer, but they can be as influenced by a metabolic landscape as cancer cells are
To evaluate the role of AGO1/2 in the miR-214-induced expression of ferroptosis-driver genes, siRNAs targeting AGO1 and AGO2 were used to knock down their expressions
