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Genome-wide association studies (GWAS) have found that sporadic PD is believed to arise from interactions between the genome and the environment and is strongly associated with common genetic variants exhibiting low-penetrance effects [23]

thaliana ortholog of the 3-phosphoadenosine 5-phosphate phosphatase SAL1 of which only Cys190 is conserved in at least one homolog of all investigated model species