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It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine

Cancer Sci 109:611617 Mauseth B, Camilio KA, Shi J, Hammarstrm CL, Rekdal , Sveinbjrnsson B, Line P-D (2019) The novel oncolytic compound LTX-401 induces antitumor immune responses in experimental hepatocellular carcinoma

(5) Research has shown that by preserving nicotinamide from NNMT-mediated degradation, the compound may enhance NAD+ synthesis through the salvage pathway

Rizzo G, Lagan AS, Rapisarda AM, La Ferrera GM, Buscema M, Rossetti P, Nigro A, Muscia V, Valenti G, Sapia F, Sarpietro G, Zigarelli M, Vitale SG