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An EGF receptor/Ral-GTPase signaling cascade regulates c-Src activity and substrate specificity

32 In this study, we develop a mechanistically detailed systems biology model of the HGF/Met signaling pathway with detailed representation of the interactions of 51 integrin with Met on the cell surface that allowed us to explore the mechanism of action for AXT050 as monotherapy and in combination with other drugs targeting the HGF pathway (i.e., sorafenib, cabozantinib, and rilotumumab)

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