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Therefore, we assumed that ACTL6A might work cooperatively with NRF2 to regulate GCLC expression

Synergistic gut microbiome-mediated degradation of Astragalus membranaceus polysaccharides and Codonopsis pilosula polysaccharides into butyric acid: a metatranscriptomic analysis

Additionally, experimental murine colitis models demonstrated that neutralizing antibodies against TNF-, IL-12, or IL-18 prevent the onset of colitis which further indicate that proinflammatory immune responses predominate in inflamed mucosa (210, 213)

MDM2 mediates the ubiquitin-dependent degradation of SPY1, resulting in a downregulation of SPY1 expression, which in turn upregulates the expression of ALOX15 and growth differentiation factor 15 (GDF15), while decreasing the levels of GCH1, GPX4, and GSH