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recently reported in vitro and in vivo activities of -galactosidase-cleavable ADCs, demonstrating that galactosidase-based drug conjugates exhibited superior therapeutic efficacy in isolated mouse plasma compared to the approved trastuzumab emtansine for breast cancer treatment

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Finally, the absence of validated biomarkers for predicting treatment response or monitoring efficacy further complicates both clinical research and practical application, limiting the ability to personalize therapy or objectively assess outcomes

They were then fused with either the N-terminal or the C-terminal half of the YFP protein-containing plasmids pVyNE and pVyCE ( Nicotiana benthamiana ) leaves via Agrobacterium tumefaciens GV2260