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Research conducted at Imperial College London demonstrated that intravenous kisspeptin-10 bolus administration produces rapid, dose-dependent increases in serum LH

High-mobility group box 1 (HMGB1), released from damaged cells, binds to Toll-like receptor 4 (TLR4) on macrophages, triggering NF-B activation and production of pro-inflammatory cytokines such as IL-1 and TNF- (98)