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Neuron 98 , 11411154.e1147 (2018)

It puts buckets under a leaking roof

As widely applied chemoradiotherapy is showing its drawbacks, such as frequent resistance and toxic side effects, cell death induction is becoming increasingly popular for developing novel cancer treatment

The hydroxyl radical is a highly reactive ROS capable of inducing oxidative damage to DNA, proteins, and lipids, thereby triggering cytotoxic effects 2