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Raetsch, C

Finally, the above approach to evaluate organoid-derived FVII function suggests that although these experiments are not specific for FVII activity per se, supernatants (supplemented with vitamin K) show hemostatic potential due to the secretion of serine proteases (probably gamma-carboxylated) into the conditioned medium that mimic the FVII effect

The limitations of this study include that the experimental findings were primarily derived from a rat model of acute myocardial ischemia, which may not fully replicate the pathophysiological complexity of human cardiovascular disease, potentially restricting the direct clinical translatability of the results

Then he went off script a little bit, as he put it