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With a median follow-up of 25.2 months, the median OS and DoR were not reached and the 12-month OS rate was 91.3%

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Moreover, UDCA significantly normalizes liver enzymes within the initial 3 months of treatment, enhances lipid profiles, and alleviates hepatic steatosis independently of weight loss

126 LiuJ.ZhangJ

Therefore, carbohydrate metabolism, is a hub of different kinds of material metabolism, which can be divided into glycolysis, aerobic oxidation, the pentose phosphate pathway (PPP), the uronic acid pathway, the polyol pathway, glycogen synthesis and glycogenolysis, gluconeogenesis, etc