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Additional changes include permitting continued participation by ACOs whose number of assigned beneficiaries falls below 5,000 during their agreement period

These were in the cerebellum (ibuprofen [238], paracetamol [239]), the cerebral cortex (diclofenac [240,241], celecoxib [201]), the frontoparietal cortex (concussive brain trauma) [231], the hippocampus and the cerebral cortex (insulin) [242], and the parietal neocortex and the hippocampus (cuprizone [232])

In most cases, they can be managed with simple measures such as reducing irritation, supporting absorption, and avoiding repeated pressure on the same area, without affecting treatment effectiveness

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